3-Methoxyphenethylamine → HCID 57978174, compound

HRID 1866563Notes

Reaction equation

HRID 1866563 reaction equation
[Si:1]([O:8][C@H:9]([C:25]1[CH:30]=[CH:29][C:28]([OH:31])=[C:27]([CH2:32][OH:33])[CH:26]=1)[CH2:10][NH:11][C:12]([CH3:24])([CH3:23])[CH2:13][C:14]1[CH:15]=[C:16]([CH:20]=[CH:21][CH:22]=1)[C:17]([OH:19])=O)([C:4]([CH3:7])([CH3:6])[CH3:5])([CH3:3])[CH3:2].[CH3:34][O:35][C:36]1[CH:37]=[C:38]([CH:42]=[CH:43][CH:44]=1)[CH2:39][CH2:40][NH2:41]>>[Si:1]([O:8][C@H:9]([C:25]1[CH:30]=[CH:29][C:28]([OH:31])=[C:27]([CH2:32][OH:33])[CH:26]=1)[CH2:10][NH:11][C:12]([CH3:24])([CH3:23])[CH2:13][C:14]1[CH:15]=[C:16]([CH:20]=[CH:21][CH:22]=1)[C:17]([NH:41][CH2:40][CH2:39][C:38]1[CH:42]=[CH:43][CH:44]=[C:36]([O:35][CH3:34])[CH:37]=1)=[O:19])([C:4]([CH3:6])([CH3:5])[CH3:7])([CH3:3])[CH3:2]

Participants

3

Reactant 2

HCID 748663-MethoxyphenethylamineHCID 579783093-{2-[(2R)-2-(tert-butyldimethyl silanyloxy)-2-(4-hydroxy-3-hydroxymethyl-phenyl)ethylamino]-2-methylpropyl}benzoic acid

Product 1

HCID 57978174HCID 57978174, compoundYield 98%

Procedure

The title compound was prepared from 3-{2-[(2R)-2-(tert-butyldimethylsilanyloxy)-2-(4-hydroxy-3-hydroxy methyl-phenyl)ethylamino]-2-methylpropyl}benzoic acid (preparation 37) and 3-methoxyphenethylamine, using a similar method to that of preparation 158, in 98% yield.

Workup

  1. customof preparation 158

Sources & evidence

ORD record
ord-f7ee2f9b831d4106b4725fc4b9740b39
Source dataset
uspto-grants-2009_12
Patent number
US07629358B2

Reaction notes

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