HRID1866563

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID74866

3-Methoxyphenylethylamine

C9H13NO

反应SMILES：CC(C)(Cc1cccc(C(=O)O)c1)NC[C@H](O[Si](C)(C)C(C)(C)C)c1ccc(O)c(CO)c1

HCID57978309

未命名化合物

PRODUCTS

产物

反应SMILES：COc1cccc(CCNC(=O)c2cccc(CC(C)(C)NC[C@H](O[Si](C)(C)C(C)(C)C)c3ccc(O)c(CO)c3)c2)c1

HCID57978174

未命名化合物

收率 98%

PROCEDURE

实验过程

The title compound was prepared from 3-{2-[(2R)-2-(tert-butyldimethylsilanyloxy)-2-(4-hydroxy-3-hydroxy methyl-phenyl)ethylamino]-2-methylpropyl}benzoic acid (preparation 37) and 3-methoxyphenethylamine, using a similar method to that of preparation 158, in 98% yield.

WORKUP

后处理

customof preparation 158

来源与证据

来源类型: Open Reaction Database
ORD记录: ord-f7ee2f9b831d4106b4725fc4b9740b39
来源数据集: uspto-grants-2009_12
DOI: 10.6084/m9.figshare.5104873.v1
专利号: US07629358B2
来源说明: uspto-grants-2009_12

反应SMILES

[Si:1]([O:8][C@H:9]([C:25]1[CH:30]=[CH:29][C:28]([OH:31])=[C:27]([CH2:32][OH:33])[CH:26]=1)[CH2:10][NH:11][C:12]([CH3:24])([CH3:23])[CH2:13][C:14]1[CH:15]=[C:16]([CH:20]=[CH:21][CH:22]=1)[C:17]([OH:19])=O)([C:4]([CH3:7])([CH3:6])[CH3:5])([CH3:3])[CH3:2].[CH3:34][O:35][C:36]1[CH:37]=[C:38]([CH:42]=[CH:43][CH:44]=1)[CH2:39][CH2:40][NH2:41]>>[Si:1]([O:8][C@H:9]([C:25]1[CH:30]=[CH:29][C:28]([OH:31])=[C:27]([CH2:32][OH:33])[CH:26]=1)[CH2:10][NH:11][C:12]([CH3:24])([CH3:23])[CH2:13][C:14]1[CH:15]=[C:16]([CH:20]=[CH:21][CH:22]=1)[C:17]([NH:41][CH2:40][CH2:39][C:38]1[CH:42]=[CH:43][CH:44]=[C:36]([O:35][CH3:34])[CH:37]=1)=[O:19])([C:4]([CH3:6])([CH3:5])[CH3:7])([CH3:3])[CH3:2]