Sulfuric Acid → Clopidogrel

Participants

Reaction Conditions

Reaction Steps

In yet another aspect, Form II of clopidogrel is prepared from ethyl acetate at a lower temperature of 5° to 15° C. comprising the steps of dissolving (+) clopidogrel base in ethyl acetate at 25° to 30° C., cool to 5° to 15° C. and mixing with conc. sulphuric acid at the said temperature, maintaining the mass under stirring for a period of 8 to 10 hours at 5 to 15° C. to yield crystals of clopidogrel Form II. The crystals obtained are filtered and dried and is identified as Form II by PXRD, FTIR and DSC without detectable contamination of Form I.

Provenance & Evidence