Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | 1,1-Dichloroethane | HCID 6365 | — |
| Reactant | Sodium Carbonate | HCID 10340 | — |
| Reactant | 4,5,6,7-Tetrahydrothieno(3,2-c)pyridinium chloride | HCID 10176342 | — |
| Reactant | HCID 131727823 | HCID 131727823 | — |
| Solvent | Water | HCID 962 | — |
| Product | Clopidogrel | HCID 60606 | — |
Reaction Steps
50 gm. of 4,5,6,7-tetrahydrothieno(3,2-c)pyridine hydrochloride was charged in 1 liter reaction vessel containing 500 ml. water and 75.4 gm. sodium carbonate and stirred for 1 hour. 75 gm. of methyl-1-bromo-(2-chlorophenyl) acetate in 250 ml. dichloroethane was added, stirred at 25° C. for 8 hours. The organic layer was separated and washed with water, and distilled the dichloroethane to obtain Clopidogrel base as an oil.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US07629465B2 |
|---|
| Source dataset | uspto-grants-2009_12 |
|---|
| ORD ID | ord-e8b4827a21f2401a904515b5411ad34f |
|---|
| Source note | uspto-grants-2009_12 |
|---|
