Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Ammonia | HCID 222 | — |
| Reactant | Benzoic acid, 3-methyl-2-nitro-, methyl ester | HCID 79621 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | 3-Methyl-2-nitrobenzamide | HCID 3271371 | — |
Reaction Steps
Methyl 3-methyl-2-nitrobenzoate (10.02 g, 51.3 mmol) was added to a 7N solution of ammonia in methanol (50 mL) and the mixture was heated at 100° C. in a Fisher-Porter tube for 3 hours. The solution was then cooled, concentrated and triturated with dichloromethane to give the title compound of Step A as a white solid (1.4 g).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US07629463B2 |
|---|
| Source dataset | uspto-grants-2009_12 |
|---|
| ORD ID | ord-6f633d8375f445e8bc7654b64a505ac9 |
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| Source note | uspto-grants-2009_12 |
|---|
