HCID 10201990, compound → HCID 21114424, compound

Participants

Reaction Steps

The product of example 2 (204 mg, 0.49 mmol) in THF was treated dropwise with Oxone® (0.307 g, 0.5 mmol) in H2O (10 mL). The mixture was stirred at 23° for 2 h, diluted with EtOAc (100 mL) and washed with H2O (2×25 mL) and satd aq NaCl (25 mL), dried (Na2SO4), and concentrated. The residue was purified by prep hplc to afford the sulfoxide as a white powder. LC MS m/z=433 (MH+), Rt=1.70 min

Provenance & Evidence