2,3-Dihydroxybutanedioic Acid → Butanedioic acid, 2,3-bis(benzoyloxy)-, (2S,3S)-

Participants

Reaction Steps

producing a chiral salt of III′ by treating the compound of formula (III′) with a chiral resolving agent (e.g., tartaric acid, mandelic acid, Mosher's acid, camphor sulphonic acid, etc., or, preferably, (+)-2,3-dibenzoyl-D-tartaric acid to yield a chiral salt (e.g., (3S,4R)-enantiomer (+)-2,3-dibenzoyl-D-tartrate salt when (+)-2,3-dibenzoyl-D-tartaric acid is the chiral resolving agent)) and isolating the cis isomer of III′ thereby produced;

Provenance & Evidence