HCID 71467943, compound → Cefprozil hydrate

HRID 1866793Notes

Reaction equation

HRID 1866793 reaction equation
[CH3:1]/[CH:2]=[CH:3]/[C:4]1[CH2:24][S:23][C@@H:7]2[C@H:8]([NH:11][C:12]([C@H:14]([NH2:22])[C:15]3[CH:16]=[CH:17][C:18]([OH:21])=[CH:19][CH:20]=3)=[O:13])[C:9](=[O:10])[N:6]2[C:5]=1[C:25]([OH:27])=[O:26].CN(C)C=[O:31]>O>[CH3:1]/[CH:2]=[CH:3]/[C:4]1[CH2:24][S:23][C@@H:7]2[C@H:8]([NH:11][C:12]([C@H:14]([NH2:22])[C:15]3[CH:16]=[CH:17][C:18]([OH:21])=[CH:19][CH:20]=3)=[O:13])[C:9](=[O:10])[N:6]2[C:5]=1[C:25]([OH:27])=[O:26].[OH2:31]

Participants

3

Reactant 1

HCID 71467943HCID 71467943, compound

Product 1

HCID 6436628Cefprozil hydrateYield 78.3%

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

The mixture of Cefprozil dimethylformamide solvate (58 gm, obtained in step-II) and water (100 ml) is stirred for 1 hour, filtered, washed with acetone (100 ml) and dried under vacuum at 40-45° C. to give 40 gm of cefprozil monohydrate (containing 10% E-isomer).

Workup

  1. filtrationfiltered
  2. washwashed with acetone (100 ml)
  3. customdried under vacuum at 40-45° C.

Sources & evidence

ORD record
ord-3e3af3b1dfbe44ff93264d3def3fbc92
Source dataset
uspto-grants-2009_12
Patent number
US07629482B2

Reaction notes

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