Tris(propan-2-yl)silanethiol → HCID 69023603, compound

Participants

Reaction Conditions

Reaction Steps

[2-(2-Bromo-5-fluoro-phenyl)-ethyl]-methyl-carbamic acid tert-butyl ester (3.0 g, 9.03 mmol), tris(dibenzylideneacetone)dipalladium (0) (83 mg, 0.09 mmol), bis(2-diphenylphosphinophenyl)ether (97 mg, 0.18 mmol), sodium tert-butoxide (1.10 g, 11.7 mmol), triisopropylsilanethiol (1.90 g, 9.93 mmol) and dry toluene (15 mL) are all placed in an Emrys Optimizer EXP 20 mL microwave reactor tube. The reaction vessel is sealed and subjected to microwave heating at 160° C. for 15 minutes. Upon cooling the mixture is poured onto a plug of silica and the product is eluted with ethyl acetate-heptane (1:10). This furnishes 1.6 g (40%) of the title compound as an oil, which is used in the next step without further purification.

Provenance & Evidence