HCID 178465384, compound → HCID 178463402, compound

HRID 1866841Notes

Reaction equation

HRID 1866841 reaction equation
C(OC(=O)[NH:10][CH:11]([C:13]1[NH:14][CH:15]=[C:16]([C:18]2[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=2)[N:17]=1)[CH3:12])C1C=CC=CC=1>CO.[Pd]>[C:18]1([C:16]2[N:17]=[C:13]([CH:11]([NH2:10])[CH3:12])[NH:14][CH:15]=2)[CH:19]=[CH:20][CH:21]=[CH:22][CH:23]=1

Participants

4

Reactant 1

HCID 178465384HCID 178465384, compound

Product 1

HCID 178463402HCID 178463402, compound

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 887MethanolSolvent

Procedure

To a solution of [1-(4-phenyl-1H-imidazol-2-yl)-ethyl]-carbamic acid benzyl ester (1.5 g, 4.67 mmol) in methanol (25 mL) was added 10% palladium on carbon (0.16 g). The mixture was shaken in a hydrogenation apparatus at rt under a hydrogen atmosphere (10 psi) for 8 h. Filtration followed by evaporation to dryness under reduced pressure yielded the crude product 1-(4-phenyl-1H-imidazol-2-yl)-ethylamine.

Workup

  1. filtrationFiltration
  2. customfollowed by evaporation to dryness under reduced pressure

Sources & evidence

ORD record
ord-6aa684c62046453f8ade39a3e22573b3
Source dataset
uspto-grants-2009_12
Patent number
US07629488B2

Reaction notes

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