HCID 54724162, compound → HCID 22050728, compound

HRID 1866888Notes

Reaction equation

HRID 1866888 reaction equation
[F:1][C:2]1[CH:3]=[C:4]([CH:14]=[CH:15][CH:16]=1)[CH2:5][N:6]1[CH:11]=[CH:10][C:9](O)=[CH:8][C:7]1=[O:13]>C(N)C1C=CC=CC=1>[CH2:5]([NH:6][C:9]1[CH:10]=[CH:11][N:6]([CH2:5][C:4]2[CH:14]=[CH:15][CH:16]=[C:2]([F:1])[CH:3]=2)[C:7](=[O:13])[CH:8]=1)[C:4]1[CH:14]=[CH:15][CH:16]=[CH:2][CH:3]=1

Participants

3

Reactant 1

HCID 54724162HCID 54724162, compound

Product 1

HCID 22050728HCID 22050728, compound

Reagents, catalysts & solvents 1

HCID 7504BenzylamineSolvent

Conditions

Temperature
185 °C

Procedure

Heated a reaction mixture of 1-(3-fluorobenzyl)-4-hydroxypyridin-2(1H)-one (1.005 g, 4.5 mmol) in benzylamine (15 mL) at reflux (185° C.) under nitrogen atmosphere for 24 h. The reaction was monitored by ES-MS (MH+ 309). The solvent was removed by vacuum distillation to give a yellow residue.

Workup

  1. temperatureHeated
  2. customThe solvent was removed by vacuum distillation
  3. customto give a yellow residue

Sources & evidence

ORD record
ord-9d42dfe6635043a7aaf1bb4fc7097247
Source dataset
uspto-grants-2009_12
Patent number
US07629363B2

Reaction notes

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