反应详情

A mixture of 1-[(4-amino-2-methylpyrimidin-5-yl)methyl]-4-hydroxy-6-methylpyridin-2(1H)-one (0.5 g, 0.002 mol), and NBS (0.4 g, 0.002 mol)in glacial acetic acid (5.0 ml) was stirred at room temperature for 1 h under argon atmosphere. Acetic acid was removed in vacuo, residue was triturated with EtOAc containing 10% EtOH, and filtered. The pale yellow precipitate was washed with EtOAc containing 10% EtOH and dried in vacuo to afford the title compound (0.47 g, 725) as a pale yellow powder:

1. customAcetic acid was removed in vacuo, residue
2. customwas triturated with EtOAc containing 10% EtOH
3. filtrationfiltered
4. washThe pale yellow precipitate was washed with EtOAc containing 10% EtOH
5. customdried in vacuo