Aluminium lithium hydride → HCID 69031225, compound

Participants

Reaction Steps

(3R*,11S*)-11-Methyl-1-oxadispiro[2.0.6.3]tridecan-13-one (800 mg, 3.84 mmol) was reduced with lithium aluminum hydride (440 mg, 11.5 mmol) in Et2O (2 mL+4 mL) at ambient temp. for 16 h. Quenching with water (5 mL) and aq. HCl (5 N, 5 mL), usual extraction and purification by silica-gel FC (pentane/Et2O, 2:1, Rf=0.16) furnished (1R*,2R*,4S*)-/(1R*,2S*,4S*)-1,4-dimethylspiro[4.6]undecane-1,2-diol (620 mg, 76%).

Provenance & Evidence