O-Phenylenediamine → HCID 15710569, compound

HRID 1867235Notes

Reaction equation

HRID 1867235 reaction equation
[NH:1]1[CH2:5][C:4](=O)[CH2:3][C:2]1=[O:7].[C:8]1([NH2:15])[CH:13]=[CH:12][CH:11]=[CH:10][C:9]=1[NH2:14]>CO>[NH2:14][C:9]1[CH:10]=[CH:11][CH:12]=[CH:13][C:8]=1[NH:15][C:4]1[CH2:5][NH:1][C:2](=[O:7])[CH:3]=1

Participants

4

Reactant 2

HCID 7243O-PhenylenediamineHCID 5514912,4-Pyrrolidinedione

Product 1

HCID 15710569HCID 15710569, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

A solution of pyrrolidin-2,4-dione (6.93 g, 70 mmol) produced in step 1 and 1,2-phenylenediamine (7.88 g, 70 mmol) in methanol was stirred at 60° C. for 1 hour. The reaction solution was cooled, and the crystals thus formed were taken by the filtration to synthesize 4-((2-aminophenyl)amino)-3-pyrrolin-2-one (yield: 11.6 g, 87%).

Workup

  1. temperatureThe reaction solution was cooled
  2. customthe crystals thus formed
  3. filtrationwere taken by the filtration
  4. customto synthesize 4-((2-aminophenyl)amino)-3-pyrrolin-2-one (yield: 11.6 g, 87%)

Sources & evidence

ORD record
ord-1fe49092966345a989bbd4cb9e47e671
Source dataset
uspto-grants-2009_12
Patent number
US07632830B2

Reaction notes

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