HuagongsheHuagongshe Chemistry Print Report · For research reference only
tert-butyl N-(2-methyl-4-oxobutan-2-yl)carbamate → Tert-butyl {3-[2-(1-hydroxycyclohexyl)phenylamino]-1,1-dimethylpropyl}carbamate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | tert-butyl N-(2-methyl-4-oxobutan-2-yl)carbamate | HCID 11788901 | — |
| Reactant | 1-(2-Aminophenyl)cyclohexan-1-ol | HCID 13554528 | — |
| Solvent | Ethyl acetate hexane | HCID 21226206 | — |
| Product | Tert-butyl {3-[2-(1-hydroxycyclohexyl)phenylamino]-1,1-dimethylpropyl}carbamate | HCID 86600982 | — |
Reaction Steps
The product is prepared analogously to intermediate product 1b starting from 1-(2-aminophenyl)cyclohexanol and tert-butyl (1,1-dimethyl-3-oxopropyl)carbamate. After column chromatography (silica gel, hexane/EtOAc 7:1) the product is obtained as a colorless oil. Yield: 2.65 g (66%); Rf=0.50 (silica gel, hexane/EtOAc 4:1).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07632834B2 |
| Source dataset | uspto-grants-2009_12 |
| ORD ID | ord-1b832b0984ef41dd9a1e0b28b320d152 |
| Source note | uspto-grants-2009_12 |