Hydrazine → HCID 68432913, compound

Participants

Reaction Steps

A suspension of 0.80 g (3.04 mmol) of 1-[(benzyloxy)carbonyl]-4-piperidinecarboxylic acid and 0.25 g (3.34 mmol) in 28 ml CH2Cl2 of N-acethyl hydrazine was treated at 0° C. with 0.73 g (3.80 mmol) of EDCI. Over night, the suspension was naturally warmed to RT, poured on aqueous 10% KHSO4 solution and extracted with CH2Cl2 (3×). The organic phases were washed with aqueous saturated NaHCO3 and aqueous 10% NaCl, dried (Na2SO4) and evaporated to give 0.84 g (87%) of the title compound as white solid. MS: 320.2 (MH+).

Provenance & Evidence