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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1867377Generated: October 31, 2026

1-[(E)-3-(3-Chloro-4-fluoro-phenyl)-acryloyl]-[1,4]diazepan-5-one → 1-[(E)-3-(3-Chloro-4-fluoro-phenyl)-acryloyl]-4-((R)-2-oxiranyl-ethyl)-[1,4]diazepan-5-one

https://huagongshe.com/reaction/1867377

Reaction equation

Participants

RoleNameHCIDCharge
Reactant1-[(E)-3-(3-Chloro-4-fluoro-phenyl)-acryloyl]-[1,4]diazepan-5-oneHCID 62046762—
Reactantmethanesulfonic acid 2-((R)-2,2-dimethyl-[1,3]dioxolan-4-yl)-ethyl esterHCID 86615867—
Product1-[(E)-3-(3-Chloro-4-fluoro-phenyl)-acryloyl]-4-((R)-2-oxiranyl-ethyl)-[1,4]diazepan-5-oneHCID 86615866—

Reaction Steps

In analogy to the procedure described for example 172A to 172C, 1-[(E)-3-(3-Chloro-4-fluoro-phenyl)-acryloyl]-[1,4]diazepan-5-one (intermediate 54) and methanesulfonic acid 2-((R)-2,2-dimethyl-[1,3]dioxolan-4-yl)-ethyl ester gave the title compound as pink oil. MS: 367.0 (MH+, 1Cl).

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS07632829B2
Source datasetuspto-grants-2009_12
ORD IDord-556de157133246f0825d878f22f5a6ac
Source noteuspto-grants-2009_12