1-Benzyl-3-methyl-1,4-diazepan-5-one → 3-Methyl-1,4-diazepan-5-one

HRID 1867387Notes

Reaction equation

HRID 1867387 reaction equation
C([N:8]1[CH2:14][CH2:13][C:12](=[O:15])[NH:11][CH:10]([CH3:16])[CH2:9]1)C1C=CC=CC=1>C(O)C.[Pd]>[CH3:16][CH:10]1[NH:11][C:12](=[O:15])[CH2:13][CH2:14][NH:8][CH2:9]1

Participants

4

Reactant 1

HCID 684323731-Benzyl-3-methyl-1,4-diazepan-5-one

Product 1

HCID 684340363-Methyl-1,4-diazepan-5-oneYield 101.4%

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 702EthanolSolvent

Procedure

A mixture of 1-benzyl-3-methyl-[1,4]diazepan-5-one (1.88 g, 8.62 mmol) and palladium (10% on activated charcoal, 188 mg) in ethanol (50 ml) was stirred at room temperature under a hydrogen atmosphere (3 bar). After 18 h, the catalyst was removed by filtration and the filtrate evaporated to afford the title compound (1.12 g, 99%). White solid, MS: m/e=128 (M+).

Workup

  1. customthe catalyst was removed by filtration
  2. customthe filtrate evaporated

Sources & evidence

ORD record
ord-cbc7d36e98224cc0ba61da0a9a4e1cfb
Source dataset
uspto-grants-2009_12
Patent number
US07632829B2

Reaction notes

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