HCID 68434037, compound → Hexahydro-7-methyl-5H-1,4-diazepin-5-one

HRID 1867389Notes

Reaction equation

HRID 1867389 reaction equation
C(OC([N:11]1[CH:17]([CH3:18])[CH2:16][C:15](=[O:19])[NH:14][CH2:13][CH2:12]1)=O)C1C=CC=CC=1>C(O)C.[Pd]>[CH3:18][CH:17]1[NH:11][CH2:12][CH2:13][NH:14][C:15](=[O:19])[CH2:16]1

Participants

4

Reactant 1

HCID 68434037HCID 68434037, compound

Product 1

HCID 45117250Hexahydro-7-methyl-5H-1,4-diazepin-5-oneYield 82.1%

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 702EthanolSolvent

Procedure

A mixture of 7-methyl-5-oxo-[1,4]diazepane-1-carboxylic acid benzyl ester (201 mg, 0.77 mmol) and palladium (10% on activated charcoal, 80 mg) in ethanol (2 ml) was stirred at room temperature under a hydrogen atmosphere (3 bar). After 20 h, the catalyst was removed by filtration and the filtrate evaporated to afford the title compound (81 mg, 82%). White solid,

Workup

  1. customthe catalyst was removed by filtration
  2. customthe filtrate evaporated

Sources & evidence

ORD record
ord-9ad9ecf658c14e3e84ccf9d299552800
Source dataset
uspto-grants-2009_12
Patent number
US07632829B2

Reaction notes

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