Methyl 3-([(benzyloxy)carbonyl]amino)propanoate → HCID 66783129, compound

HRID 1867390Notes

Reaction equation

HRID 1867390 reaction equation
CO[C:3](=[O:17])[CH2:4][CH2:5][NH:6][C:7]([O:9][CH2:10][C:11]1[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=1)=[O:8].C(OC([N:25]1[CH2:29][C@H:28]([CH3:30])OS1(=O)=O)=O)(C)(C)C>>[CH2:10]([O:9][C:7]([N:6]1[CH2:5][CH2:4][C:3](=[O:17])[NH:25][CH2:29][C@H:28]1[CH3:30])=[O:8])[C:11]1[CH:12]=[CH:13][CH:14]=[CH:15][CH:16]=1

Participants

3

Reactant 2

HCID 376763Methyl 3-([(benzyloxy)carbonyl]amino)propanoateHCID 11195739(s)-Tert-butyl 5-methyl-1,2,3-oxathiazolidine-3-carboxylate 2,2-dioxide

Product 1

HCID 66783129HCID 66783129, compound

Procedure

In analogy to the procedure described in intermediate 78A, 3-benzyloxycarbonylamino-propanoic acid methyl ester and (S)-5-methyl-2,2-dioxo-[1,2,3]oxathiazolidine-3-carboxylic acid tert-butyl ester (Bioorg. Med. Chem. Lett. 2006, 16, 1207) gave the title compound. Colorless gum, MS: m/e=263.1 (MH+).

Sources & evidence

ORD record
ord-66270e3f29d7482c9913920ad9a040be
Source dataset
uspto-grants-2009_12
Patent number
US07632829B2

Reaction notes

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