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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1867391Generated: October 26, 2026

3,4-Dichlorocinnamic acid → (R)-1-[(E)-3-(3,4-Dichloro-phenyl)-acryloyl]-2-methyl-[1,4]diazepan-5-one

https://huagongshe.com/reaction/1867391

Reaction equation

Participants

RoleNameHCIDCharge
Reactant3,4-Dichlorocinnamic acidHCID 688027—
Reactant(R)-2-methyl-[1,4]diazepan-5-oneHCID 28064214—
Product(R)-1-[(E)-3-(3,4-Dichloro-phenyl)-acryloyl]-2-methyl-[1,4]diazepan-5-oneHCID 68432228—

Reaction Steps

In analogy to the procedure described in intermediate 78C, (E)-3,4-dichlorocinnamic acid and (R)-2-methyl-[1,4]diazepan-5-one gave the title compound as a colorless gum, MS: m/e=327.3 (MH+).

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS07632829B2
Source datasetuspto-grants-2009_12
ORD IDord-8141f72d1a7e473faea850fcd678cc96
Source noteuspto-grants-2009_12