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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1867402Generated: October 25, 2026

Piperidine, 1-(3-chloropropyl)- → 1-[(E)-3-(3,4-Dichloro-phenyl)-acryloyl]-4-(3-piperidin-1-yl-propyl)-[1,4]diazepan-5-one

https://huagongshe.com/reaction/1867402

Reaction equation

Participants

RoleNameHCIDCharge
ReactantPiperidine, 1-(3-chloropropyl)-HCID 79625—
Reactant1-[(E)-3-(3,4-Dichloro-phenyl)-acryloyl]-[1,4]diazepan-5-oneHCID 62044921—
Product1-[(E)-3-(3,4-Dichloro-phenyl)-acryloyl]-4-(3-piperidin-1-yl-propyl)-[1,4]diazepan-5-oneHCID 68431984—

Reaction Steps

In analogy to the procedure described in intermediate 4A, 1-[(E)-3-(3,4-dichloro-phenyl)-acryloyl]-[1,4]diazepan-5-one (intermediate 1A) and 1-(3-chloro-propyl)-piperidine gave the title compound as light yellow solid. MS: 438.1 (MH+, 2Cl).

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS07632829B2
Source datasetuspto-grants-2009_12
ORD IDord-dffcd76c2a09470dad9f779a88f90324
Source noteuspto-grants-2009_12