Back
HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1867407Generated: October 25, 2026

2-(3-Bromopropoxy)tetrahydro-2H-pyran → 1-[(E)-3-(3,4-Dichloro-phenyl)-acryloyl]-4-[3-(tetrahydro-pyran-2-yloxy)-propyl]-[1,4]diazepan-5-one

https://huagongshe.com/reaction/1867407

Reaction equation

Participants

RoleNameHCIDCharge
Reactant2-(3-Bromopropoxy)tetrahydro-2H-pyranHCID 2777988—
Reactant1-[(E)-3-(3,4-Dichloro-phenyl)-acryloyl]-[1,4]diazepan-5-oneHCID 62044921—
Product1-[(E)-3-(3,4-Dichloro-phenyl)-acryloyl]-4-[3-(tetrahydro-pyran-2-yloxy)-propyl]-[1,4]diazepan-5-oneHCID 68435254—

Reaction Steps

In analogy to the procedure described in example 5A, 1-[(E)-3-(3,4-dichloro-phenyl)-acryloyl]-[1,4]diazepan-5-one (intermediate 1A]) and 2-(3-bromo-propoxy)-tetrahydro-pyran gave the title compound as white solid. MS: 455.3 (MH+, 2Cl).

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS07632829B2
Source datasetuspto-grants-2009_12
ORD IDord-dce800a603834be19375384a5461168c
Source noteuspto-grants-2009_12