1-Chloro-4-iodobutane → 4-(4-Chloro-butyl)-1-[(E)-3-(3,4-dichloro-phenyl)-acryloyl]-[1,4]diazepan-5-one

HRID 1867414Notes

Reaction equation

HRID 1867414 reaction equation
[Cl:1][C:2]1[CH:3]=[C:4](/[CH:9]=[CH:10]/[C:11]([N:13]2[CH2:19][CH2:18][C:17](=[O:20])[NH:16][CH2:15][CH2:14]2)=[O:12])[CH:5]=[CH:6][C:7]=1[Cl:8].[Cl:21][CH2:22][CH2:23][CH2:24][CH2:25]I>>[Cl:21][CH2:22][CH2:23][CH2:24][CH2:25][N:16]1[C:17](=[O:20])[CH2:18][CH2:19][N:13]([C:11](=[O:12])/[CH:10]=[CH:9]/[C:4]2[CH:5]=[CH:6][C:7]([Cl:8])=[C:2]([Cl:1])[CH:3]=2)[CH2:14][CH2:15]1

Participants

3

Reactant 2

HCID 825271-Chloro-4-iodobutaneHCID 620449211-[(E)-3-(3,4-Dichloro-phenyl)-acryloyl]-[1,4]diazepan-5-one2×

Product 1

HCID 684351904-(4-Chloro-butyl)-1-[(E)-3-(3,4-dichloro-phenyl)-acryloyl]-[1,4]diazepan-5-one

Procedure

In analogy to the procedure described in example 5A, 1-[(E)-3-(3,4-dichloro-phenyl)-acryloyl]-[1,4]diazepan-5-one (intermediate 1A]) and 1-chloro-4-iodobutane gave the title compound as orange solid. MS: 403.2 (MH+, 3Cl).

Sources & evidence

ORD record
ord-e9e63b27661f43ac9e2e485230c36795
Source dataset
uspto-grants-2009_12
Patent number
US07632829B2

Reaction notes

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