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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1867416Generated: October 27, 2026

Sodium Iodide → 1-[(E)-3-(3,4-Dichloro-phenyl)-acryloyl]-4-(4-piperidin-1-yl-butyl)-[1,4]diazepan-5-one

https://huagongshe.com/reaction/1867416

Reaction equation

Participants

RoleNameHCIDCharge
ReactantSodium IodideHCID 5238—
ReactantPiperidineHCID 8082—
Reactant1-[(E)-3-(3,4-dichloro-phenyl)-acryloyl]-4-(4-iodo-butyl)-[1,4]diazepan-5-oneHCID 68433016—
Product1-[(E)-3-(3,4-Dichloro-phenyl)-acryloyl]-4-(4-piperidin-1-yl-butyl)-[1,4]diazepan-5-oneHCID 16755788—

Reaction Steps

In analogy to the procedure described in example 5D, 1-[(E)-3-(3,4-dichloro-phenyl)-acryloyl]-4-(4-iodo-butyl)-[1,4]diazepan-5-one and piperidine (with no additional sodium iodide) gave the title compound as white powder. MS: 452.2 (MH+, 2Cl).

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS07632829B2
Source datasetuspto-grants-2009_12
ORD IDord-668e053d78e04ddfbb01a98570236538
Source noteuspto-grants-2009_12