Methyl iodide → HCID 68432193, compound

HRID 1867422Notes

Reaction equation

HRID 1867422 reaction equation
[Cl:1][C:2]1[CH:3]=[C:4](/[CH:9]=[CH:10]/[C:11]([N:13]2[CH2:19][CH2:18][C:17](=[O:20])[N:16]([CH2:21][CH2:22][CH2:23][N:24]3[CH2:35][CH2:34][C:27]4([NH:31][C:30](=[O:32])[NH:29][C:28]4=[O:33])[CH2:26][CH2:25]3)[CH2:15][CH2:14]2)=[O:12])[CH:5]=[CH:6][C:7]=1[Cl:8].[I:36][CH3:37]>CO>[I-:36].[Cl:1][C:2]1[CH:3]=[C:4](/[CH:9]=[CH:10]/[C:11]([N:13]2[CH2:19][CH2:18][C:17](=[O:20])[N:16]([CH2:21][CH2:22][CH2:23][N+:24]3([CH3:37])[CH2:35][CH2:34][C:27]4([NH:31][C:30](=[O:32])[NH:29][C:28]4=[O:33])[CH2:26][CH2:25]3)[CH2:15][CH2:14]2)=[O:12])[CH:5]=[CH:6][C:7]=1[Cl:8]

Participants

4

Reactant 2

HCID 6328Methyl iodideHCID 25032090HCID 25032090, compound

Product 1

HCID 68432193HCID 68432193, compoundYield 103%

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

To a solution of 8-(3-{4-[(E)-3-(3,4-Dichloro-phenyl)-acryloyl]-7-oxo-[1,4]diazepan-1-yl}-propyl)-1,3,8-triaza-spiro[4.5]decane-2,4-dione (example 48) (10 mg, 19 umol) in MeOH (0.5 ml) was added iodomethane (10 uL, 95 umol) and the reaction left for 2 days at room temperature. Concentration of the mixture affording the title product (13 mg, 98%) as a white solid. MS: 536.1 (M+, 2Cl).

Sources & evidence

ORD record
ord-199c3fe09c7d4814aea2a6c0bf5b6884
Source dataset
uspto-grants-2009_12
Patent number
US07632829B2

Reaction notes

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