Potassium tert-butoxide → HCID 68432290, compound

Participants

Reaction Steps

To a solution of {2-[Acryloyl-(1-benzyl-piperidin-4-yl)-amino]-ethyl}-carbamic acid tert-butyl ester (4.6 g, 12 mmol) in DMF (40 ml) was added potassium tert-butoxide (0.1 g, 1 mmol) and the reaction stirred for 2 h after which time it was concentrated, the residue dissolved in CH2Cl2, washed with saturated NaHCO3, dried (Na2SO4), and concentrated. The product was isolated by flash column chromatography (CH2Cl2:MeOH 9:1) to afford the title compound (3.5 g, 75%) as a white solid. MS: 388.3 (MH+)

Provenance & Evidence