Hydrochloric Acid → 1-[(E)-3-(3,4-Dichloro-phenyl)-acryloyl]-4-[4-((3RS,4SR)-3,4-dihydroxy-piperidin-1-yl)-butyl]-[1,4]diazepan-5-one hydrochlorid

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Reaction Steps

A solution of 0.100 g (0.14 mmol) of 4-{4-[(3RS,4SR)-3,4-bis-(tert-butyl-dimethyl-silanyloxy)-piperidin-1-yl]-butyl}-1-[(E)-3-(3,4-dichloro-phenyl)-acryloyl]-[1,4]diazepan-5-one in 2 mL of MeOH was cooled (0° C.), treated with 0.35 ml (1.40 mmol) of 4M HCl in dioxane and stirred at RT for 2 h. The solution was evaporated, dissolved in toluene and evaporated (2×) to yield 0.053 g (73%) of the title compound as light brown foam. MS: 484.2 (MH+, 2Cl).

Provenance & Evidence