HuagongsheHuagongshe Chemistry Print Report · For research reference only
1-[(E)-3-(3,4-Dichloro-phenyl)-acryloyl]-[1,4]diazepan-5-one → 1-[(E)-3-(3,4-Dichloro-phenyl)-acryloyl]-4-(2,2-dimethyl-3-piperidin-1-yl-propyl)-[1,4]diazepan-5-one
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1-[(E)-3-(3,4-Dichloro-phenyl)-acryloyl]-[1,4]diazepan-5-one | HCID 62044921 | — |
| Reactant | 1-(3-Iodo-2,2-dimethyl-propyl)-piperidine | HCID 68434742 | — |
| Product | 1-[(E)-3-(3,4-Dichloro-phenyl)-acryloyl]-4-(2,2-dimethyl-3-piperidin-1-yl-propyl)-[1,4]diazepan-5-one | HCID 68434448 | — |
Reaction Steps
In analogy to the procedure described for intermediate 4A, 1-[(E)-3-(3,4-dichloro-phenyl)-acryloyl]-[1,4]diazepan-5-one (intermediate 1A]) and 1-(3-iodo-2,2-dimethyl-propyl)-piperidine stirred 2 h at RT, gave the title compound as white solid. MS: 466.3 (MH+, 2Cl).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07632829B2 |
| Source dataset | uspto-grants-2009_12 |
| ORD ID | ord-6e3753ade0ff44bca06ffb3e6651e3a6 |
| Source note | uspto-grants-2009_12 |