Epibromohydrin → HCID 87452964, compound

HRID 1867447Notes

Reaction equation

[F:1][C:2]1[CH:3]=[C:4](/[CH:9]=[CH:10]/[C:11]([N:13]2[CH2:19][CH2:18][C:17](=[O:20])[NH:16][CH2:15][CH2:14]2)=[O:12])[CH:5]=[CH:6][C:7]=1[F:8].Br[CH2:22][CH:23]1[CH2:25][O:24]1>>[F:1][C:2]1[CH:3]=[C:4](/[CH:9]=[CH:10]/[C:11]([N:13]2[CH2:19][CH2:18][C:17](=[O:20])[N:16]([CH2:22][CH:23]3[CH2:25][O:24]3)[CH2:15][CH2:14]2)=[O:12])[CH:5]=[CH:6][C:7]=1[F:8]

Participants

Reactant 2

HCID 18430Epibromohydrin

HCID 68433077HCID 68433077, compound2×

Product 1

HCID 87452964HCID 87452964, compound

Procedure

In analogy to the procedure described for example 166A, 1-[(E)-3-(3,4-difluoro-phenyl)-acryloyl]-[1,4]diazepan-5-one (intermediate 55) and 2-bromomethyl-oxirane gave the title compound as yellow oil. MS: 337.2 (MH+).

Sources & evidence

ORD record: ord-760fd3ced3e24ee28186f5fcbb97d1d5
Source dataset: uspto-grants-2009_12
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07632829B2

Reaction notes

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