HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1867473Generated: November 1, 2026
Acetic Anhydride → acetic acid (1RS,3RS,4RS)-3-(3,4-dimethoxyphenyl)-4-nitrocyclohexyl ester
https://huagongshe.com/reaction/1867473
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Acetic Anhydride | HCID 7918 | — |
| Reactant | (1RS,3RS,4RS)-3-(3,4-dimethoxyphenyl)-4-nitrocyclohexanol | HCID 17989075 | — |
| Product | acetic acid (1RS,3RS,4RS)-3-(3,4-dimethoxyphenyl)-4-nitrocyclohexyl ester | HCID 67022378 | — |
Reaction Steps
6.0 g of (±)-(1SR,3RS,4SR)-3-(3,4-dimethoxyphenyl)-4-nitrocyclohexanol (compound E5) are dissolved in 40 ml of acetic anhydride and stirred for 1.5 h at 100° C. The reaction mixture is concentrated and the residual title compound of melting point 108-110° C. is used without further purification in the next step.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US07632844B2 |
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| Source dataset | uspto-grants-2009_12 |
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| ORD ID | ord-84be4edf620d450ea4f67728584961ff |
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| Source note | uspto-grants-2009_12 |
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