2-(Tributylstannyl)-1,3-thiazole → 2-(3-Fluoro-4-hydroxyphenyl)-4-thiazol-2-yl-quinolin-6-ol

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Reaction Steps

This compound was prepared from 6b and 2-tributylstannylthiazole according to method J. Yellow powder; Yield: 56%; mp>280° C. (dec.); 1H-NMR (400 MHz, DMSO-d6) δ 7.10 (t, J=8.8 Hz, 1H), 7.38 (dd, J=9.1, 2.7 Hz, 1H), 7.95-8.00 (m, 2H), 8.07-8.12 (m, 3H), 8.21 (m, 2H), 10.18 (s, 1H), 10.26 (s, 1H); MS (ESI) m/z 337 ([M−H]−), 339 ([M+H]+); Anal. Calcd for C18H11FN2O2S: C, 63.90; H, 3.28; N, 8.28. Found: C, 62.6; H, 3.43; N, 7.59.

Provenance & Evidence