Aluminum bromide → HCID 136337700, compound

Participants

Reaction Steps

140 mg (0.52 mmol) of (4-benzo[1,2,5]oxadiazol-5-yl-3-methoxy-phenyl)-dimethyl-amine are stirred at −10 to 0° C. in 1.7 mL of CH2Cl2, then over 5 minutes treated with 1.7 mL AlBr3 (1.0 M solution in CH2Br2, 3.3 eq.) and stirred another 19 h under warming to rt. Then, the mixture is extracted with brine/ethyl acetate, the combined organic layers dried with sodium sulfate and concentrated. The crude product is column chromatographed with ethyl acetate/hexanes 1:4 to yield after evaporation of the product-containing fractions the desired product as a red solid.

Provenance & Evidence