HuagongsheHuagongshe Chemistry Print Report · For research reference only
Sodium Carbonate → 3-Chloro-4'-fluoro[1,1'-biphenyl]-4-carboxylic acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Sodium Carbonate | HCID 10340 | — |
| Reactant | 4-Bromo-2-chlorobenzoic acid | HCID 108829 | — |
| Reactant | 4-Fluorophenylboronic acid | HCID 285645 | — |
| Catalyst | Tetrakis(triphenylphosphine)palladium | HCID 11979704 | — |
| Solvent | Toluene | HCID 1140 | — |
| Product | 3-Chloro-4'-fluoro[1,1'-biphenyl]-4-carboxylic acid | HCID 46314470 | — |
Reaction Steps
Under an inert atmosphere, 5 g (21.2 mmol) of 4-bromo-2-chlorobenzoic acid, 2.96 g (23.3 mmol) of 4-fluorophenylboronic acid and 31.8 ml (63.6 mmol) of aqueous sodium carbonate solution (2M) in suspension in 40 ml of toluene are introduced. Subsequently 0.80 g (0.70 mmol) of palladium tetrakis(triphenylphosphine) is added. The reaction mixture is subsequently refluxed overnight.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07632850B2 |
| Source dataset | uspto-grants-2009_12 |
| ORD ID | ord-0cb48b9257824cb096b9710ec06aae39 |
| Source note | uspto-grants-2009_12 |