Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Triethylamine | HCID 8471 | — |
| Reactant | tert-Butyl carbazate | HCID 70091 | — |
| Reactant | 5-(4-Bromophenyl)-1-(2,4-dichlorophenyl)-4-ethyl-1H-pyrazole-3-carbonyl chloride | HCID 11282549 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | HCID 86618351 | HCID 86618351 | 100.1% |
Reaction Steps
A mixture of 3.2 g of tert-butyl hydrazinecarboxylate and 3.9 ml of triethylamine in 100 ml of DCM is cooled to 0° C., a solution of 10.5 g of the compound obtained in stage A in 100 ml of DCM is added dropwise and the mixture is left stirring while allowing the temperature to rise to AT. The reaction mixture is washed with water, with a pH=2 buffer solution and with a saturated NaHCO3 solution, the organic phase is dried over MgSO4 and the solvent is evaporated under vacuum. 12.7 g of the expected compound are obtained.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US07632852B2 |
|---|
| Source dataset | uspto-grants-2009_12 |
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| ORD ID | ord-d53ea1ea28b44262a76b7e7bd0985f42 |
|---|
| Source note | uspto-grants-2009_12 |
|---|
