4-Chlororesorcinol → 4-Methoxyphenylacetaldehyde

Participants

Reaction Conditions

Reaction Steps

4-Chlororesorcinol (1 eq) and para-methoxyphenylacetic acid (1 eq) were combined in boron trifluoride diethyletherate (5 eq) and heated to 90° C. under nitrogen for 3 hours. The reaction was allowed to cool to room temperature and was then added drop wise to 10% NaOAc (aq). The mixture was allowed to stand overnight, and the subsequent solid was collected by vacuum filtration. The solid was dried under vacuum to give 1-5-chloro-2,4-dihydroxy-phenyl)-2-(4-methoxy-phenyl)-ethanone.

Provenance & Evidence