HuagongsheHuagongshe Chemistry Print Report · For research reference only
Propane, 1-chloro-3-isocyanato- → 1,1-Dimethylethyl 4-[(3-chloropropyl)amino]-1-piperidinecarboxylate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Propane, 1-chloro-3-isocyanato- | HCID 166752 | — |
| Reactant | 4-Amino-1-Boc-piperidine | HCID 1268291 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | 1,1-Dimethylethyl 4-[(3-chloropropyl)amino]-1-piperidinecarboxylate | HCID 68562572 | 97.5% |
Reaction Steps
A solution of 4-amino-1-t-butoxycarbonylpiperidine (200 mg, 1.0 mmol) in tetrahydrofuran (5 mL) was treated with 3-chloropropyl isocyanate (0.080 mL, 1.0 mmol) overnight. The solvent was evaporated to provide the title compound as a white solid (270 mg).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07632832B2 |
| Source dataset | uspto-grants-2009_12 |
| ORD ID | ord-3573dace34a4450faafa998cdcf00807 |
| Source note | uspto-grants-2009_12 |