2-Bromo-4'-methylacetophenone → HCID 68566507, compound

Participants

Reaction Steps

Sodium acetate (41 mg, 0.50 mmol) was added to a solution of t-butyl 4-aminopiperidine-1-carboxylate (100 mg, 0.50 mmol) in acetonitrile (2 mL) at 0° C. After 5 min, 2-bromo-4′-methylacetophenone (106.4 mg, 0.50 mmol) in acetonitrile (1 mL) was added and the mixture was allowed to warm to ambient temperature. After 1.5 h, sodium cyanate (97.4 mg, 1.5 mmol), acetic acid (100 uL) and water (80 uL) were added to the reaction mixture. After 16 h, the mixture was concentrated to give the title compound.

Provenance & Evidence