HCID 68565785, compound → HCID 57979566, compound

HRID 1867588Notes

Reaction equation

HRID 1867588 reaction equation
[CH2:1]([C:8]1[NH:9][C:10](=[O:26])[N:11]([CH:13]2[CH2:18][CH2:17][N:16](CC3C=CC=CC=3)[CH2:15][CH2:14]2)[CH:12]=1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1>[Pd].CO.C(O)(=O)C>[CH2:1]([C:8]1[NH:9][C:10](=[O:26])[N:11]([CH:13]2[CH2:18][CH2:17][NH:16][CH2:15][CH2:14]2)[CH:12]=1)[C:2]1[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=1

Participants

5

Reactant 1

HCID 68565785HCID 68565785, compound

Product 1

HCID 57979566HCID 57979566, compound

Reagents, catalysts & solvents 3

HCID 23938PalladiumCatalystHCID 176Acetic AcidSolventHCID 887MethanolSolvent

Procedure

10% Palladium on carbon (50 mg) was added to a solution of 4-benzyl-1-(1-benzylpiperidin-4-yl)-1,3-dihydro-2H-imidazol-2-one (100 mg, 0.287 mmol) in methanol (7.5 mL) and acetic acid (7.5 mL). The reaction vessel was evacuated and back-filled with nitrogen (3×), then back-filled with hydrogen (1 atm). After 16 h, the mixture was filtered and concentrated to give the title compound. MS 258.1 (M+1)

Workup

  1. customThe reaction vessel was evacuated
  2. additionback-filled with nitrogen (3×)
  3. additionback-filled with hydrogen (1 atm)
  4. filtrationthe mixture was filtered
  5. concentrationconcentrated

Sources & evidence

ORD record
ord-f344dd6e5c074851be19b8d104da2365
Source dataset
uspto-grants-2009_12
Patent number
US07632832B2

Reaction notes

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