HCID 18321616, compound → HCID 68565701, compound

Participants

Reaction Steps

Lithium aluminum hydride (3.96 mL, 3.96 mmol, 1 M) was added to a solution of 5-benzyl-3-(1-benzylpiperidin-4-yl)imidazolidine-2,4-dione (120 mg, 0.330 mmol) in tetrahydrofuran (15 mL) at 0° C. and then warmed to ambient temperature. After 16 h, the reaction was quenched with water (0.150 mL), a 15% sodium hydroxide solution (0.150 mL), and water (0.450 mL). The mixture was filtered, washed with tetrahydrofuran, and concentrated. Purification by column chromatography (silica gel, 1 to 12% {1% ammonium hydroxide/methanol} in methylene chloride gradient elution), gave the title compound (30 mg). MS 350.3 (M+1)

Provenance & Evidence