HuagongsheHuagongshe Chemistry Print Report · For research reference only
Trifluoroacetic acid → 4-(Hydroxymethyl)-1-piperidin-4-yl-1,3-dihydro-2H-imidazol-2-one
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Trifluoroacetic acid | HCID 6422 | — |
| Reactant | tert-Butyl 4-[4-({[tert-butyl(diphenyl)silyl]oxy}methyl)-2-oxo-2,3-dihydro-1H-imidazol-1-yl]piperidine-1-carboxylate | HCID 68567938 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | 4-(Hydroxymethyl)-1-piperidin-4-yl-1,3-dihydro-2H-imidazol-2-one | HCID 57979570 | — |
Reaction Steps
Trifluoroacetic acid (5 mL) was added to a solution of tert-butyl 4-[4-({[tert-butyl(diphenyl)silyl]oxy}methyl)-2-oxo-2,3-dihydro-1H-imidazol-1-yl]piperidine-1-carboxylate (550 mg, 1.03 mmol) in dichloromethane (15 mL). After 30 min, the reaction was concentrated to give the title compound.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07632832B2 |
| Source dataset | uspto-grants-2009_12 |
| ORD ID | ord-860197482a3a4d268622f80ca5077639 |
| Source note | uspto-grants-2009_12 |