HuagongsheHuagongshe Chemistry Print Report · For research reference only
Trifluoroacetic acid → 2-Oxo-1-piperidin-4-yl-2,3-dihydro-1H-imidazole-4-carbonitrile
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Trifluoroacetic acid | HCID 6422 | — |
| Reactant | Tert-butyl 4-(4-cyano-2-oxo-2,3-dihydroimidazol-1-yl)piperidine-1-carboxylate | HCID 59006363 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | 2-Oxo-1-piperidin-4-yl-2,3-dihydro-1H-imidazole-4-carbonitrile | HCID 59856528 | — |
Reaction Steps
Trifluoroacetic acid (4 mL) was added to a solution of tert-butyl 4-(4-cyano-2-oxo-2,3-dihydro-1H-imidazol-1-yl)piperidine-1-carboxylate (25 mg, 0.086 mmol) in dichloromethane (6 mL). After 20 min, the reaction was concentrated to give the title compound. MS 193.3 (M+1)
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07632832B2 |
| Source dataset | uspto-grants-2009_12 |
| ORD ID | ord-00b0c65137c74ce99ec0883b1ebbf94b |
| Source note | uspto-grants-2009_12 |