Lithium Hydroxide → HCID 11671386, compound

Participants

Reaction Steps

Lithium hydroxide (43 mg, 1.03 mmol) in water (2 mL) was added to a solution methyl 2-oxo-1-[1-({[(3R)-2-oxo-5-phenyl-1-(2,2,2-trifluoroethyl)-2,3-dihydro-1H-1,4-benzodiazepin-3-yl]amino}carbonyl)piperidin-4-yl]-2,3-dihydro-1H-imidazole-4-carboxylate (30 mg, 0.051 mmol) in methanol (2 mL) and heated to 40 o C. After 2 h, the reaction was purified by preparative reverse phase chromatography to give the title compound (5 mg). MS 571.2 (M+1)

Provenance & Evidence