HCID 68565139, compound → HCID 68566597, compound

HRID 1867629Notes

Reaction equation

HRID 1867629 reaction equation
[O:1]=[C:2]1[NH:6][C:5]([C:7]2[CH:12]=[CH:11][CH:10]=[CH:9][CH:8]=2)=[CH:4][N:3]1[CH:13]1[CH2:18][CH2:17][N:16]([C:19]([O:21][C@H:22]2[N:28]=[C:27]([C:29]3[CH:34]=[CH:33][CH:32]=[CH:31][CH:30]=3)[C:26]3[CH:35]=[CH:36][CH:37]=[CH:38][C:25]=3[N:24]([CH2:39][C:40]([F:43])([F:42])[F:41])[C:23]2=[O:44])=[O:20])[CH2:15][CH2:14]1.Cl.[CH3:46][O:47]C1C=C(C2NC(=O)N(C3CCNCC3)C=2)C=CC=1>>[O:1]=[C:2]1[NH:6][C:5]([C:7]2[CH:12]=[CH:11][CH:10]=[C:9]([O:47][CH3:46])[CH:8]=2)=[CH:4][N:3]1[CH:13]1[CH2:18][CH2:17][N:16]([C:19]([O:21][C@H:22]2[N:28]=[C:27]([C:29]3[CH:34]=[CH:33][CH:32]=[CH:31][CH:30]=3)[C:26]3[CH:35]=[CH:36][CH:37]=[CH:38][C:25]=3[N:24]([CH2:39][C:40]([F:43])([F:42])[F:41])[C:23]2=[O:44])=[O:20])[CH2:15][CH2:14]1

Participants

3

Reactant 2

HCID 68565139HCID 68565139, compoundHCID 68566609HCID 68566609, compound

Product 1

HCID 68566597HCID 68566597, compound

Procedure

The title compound was prepared in the same way as (3R)-2-oxo-5-phenyl-1-(2,2,2-trifluoroethyl)-2,3-dihydro-1H-1,4-benzodiazepin-3-yl 4-(2-oxo-4-phenyl-2,3-dihydro-1H-imidazol-1-yl)piperidine-1-carboxylate, except using 4-(3-methoxyphenyl)-1-piperidin-4-yl-1,3-dihydro-2H-imidazol-2-one hydrochloride in place of 4-phenyl-1-piperidin-4-yl-1,3-dihydro-2H-imidazol-2-one hydrochloride. MS 634.2266 (M+1)

Sources & evidence

ORD record
ord-bdc7ce1c4013491bb3c2736f0b64131a
Source dataset
uspto-grants-2009_12
Patent number
US07632832B2

Reaction notes

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