HCID 57691462, compound → HCID 57691453, compound

Participants

Reaction Conditions

Reaction Steps

To a solution of 1-(2-(1,3-dioxan-2-yl)phenyl)-2-(3,5-bis(trifluoromethyl)benzyloxy)ethanone (1.06 g, 2.36 mmol) in tetrahydrofuran (15 mL) at −78° C. was added vinylmagnesium bromide (1 M in tetrahydrofuran, 4.73 mL, 4.73 mmol). The reaction was allowed to warm to −60° C. in the Dewar flask before quenching with saturated ammonium chloride. The reaction was poured into diethyl ether, washed with water, then brine, dried over magnesium sulfate, and concentrated. Column chromatography (12%-->25% EtOAc/Hex) gave 810 mg (72%) as a colorless oil. Mass spec.: 499.30 (MNa)+.

Provenance & Evidence