Hydrochloric Acid → HCID 57691458, compound

Participants

Reaction Steps

To a solution of 2-(2-(1,3-dioxan-2-yl)phenyl)-1-(3,5-bis(trifluoromethyl)benzyloxy)but-3-en-2-ol (800 mg, 1.68 mmol) in acetone (20 mL) and water (1 mL) was added concentrated hydrochloric acid (0.2 mL) at room temperature. The resulting reaction was stirred at room temperature for 2 h. The reaction was quenched by addition of saturated sodium bicarbonate, and concentrated to remove most of the acetone. The mixture was poured into diethyl ether, washed with water, then brine, dried over magnesium sulfate, and concentrated. Column chromatography (25%-->50% EtOAc/Hex) gave 475 mg (68%) as a colorless oil. Mass spec.: 401.32 (M-OH)+.

Provenance & Evidence