HuagongsheHuagongshe Chemistry Print Report · For research reference only
Water → N-(4-(3-chloro-5-trifluoromethyl-2-pyridyloxy)phenyl)-4-chloronicotinamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Water | HCID 962 | — |
| Reactant | Triethylamine | HCID 8471 | — |
| Reactant | 4-{[3-Chloro-5-(trifluoromethyl)pyridin-2-yl]oxy}aniline | HCID 2764116 | — |
| Reactant | 4-Chloronicotinoyl chloride hydrochloride | HCID 23152008 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | N-(4-(3-chloro-5-trifluoromethyl-2-pyridyloxy)phenyl)-4-chloronicotinamide | HCID 23151884 | — |
Reaction Steps
A solution of 150 mg of 4-(3-chloro-5-trifluoromethyl-2-pyridyloxy)aniline and 116 mg of triethylamine in 5 mL of tetrahydrofuran was stirred with 100 mg of 4-chloronicotinoyl chloride hydrochloride for about 50 minutes, and after addition of water, the precipitated crystals were recovered by filtration. The recovered crystals were washed with ether and dried to 106 mg of N-(4-(3-chloro-5-trifluoromethyl-2-pyridyloxy)phenyl)-4-chloronicotinamide having a melting point of 178-180° C. (decomposition).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07632865B2 |
| Source dataset | uspto-grants-2009_12 |
| ORD ID | ord-afe8394e47b649088fd1799f755c126a |
| Source note | uspto-grants-2009_12 |