Hydrochloric Acid → 4-[({4-[(3-Chloro-2-fluorophenyl)amino]-7-methoxyquinazolin-6-yl}methyl)(methyl)amino]piperidine-4-carboxylic acid

Participants

Reaction Steps

1-(tert-butoxycarbonyl)-4-[({4-[(3-chloro-2-fluorophenyl)amino]-7-methoxyquinazolin-6-yl}methyl)(methyl)amino]piperidine-4-carboxylic acid (prepared as described in Example 16) was deprotected by treating the compound with hydrogen chloride in dioxane using an analogous method to that described for the equivalent step in Example 7 to give 4-[({4-[(3-chloro-2-fluorophenyl)amino]-7-methoxyquinazolin-6-yl}methyl)(methyl)amino]piperidine-4-carboxylic acid; 1H NMR Spectrum: (DMSO-d6+CD3COOD) 2.06 (m, 2H); 2.15 (m, 2H); 2.26 (s, 3H); 3.04 (m, 2H); 3.27 (m, 2H); 3.75 (s, 2H); 3.96 (s, 3H); 7.21 (s, 1H); 7.28 (m, 1H); 7.48 (m, 1H); 7.54 (m, 1H); 8.32 (s, 1H); 8.42 (S, 1H). Mass Spectrum: (M+H)+ 474.

Provenance & Evidence