2-Morpholinoethylamine → HCID 57979879, compound

Participants

Reaction Steps

4-(3-Chloro-2-fluoroanilino)-7-methoxyquinazoline-6-carbaldehyde was coupled with (2-morpholin-4-ylethyl)amine using an analogous method to that described for the equivalent step in Example 1 to give N-(3-chloro-2-fluorophenyl)-7-methoxy-6-{[(2-morpholin-4-ylethyl)amino]methyl}quinazolin-4-amine; 1H NMR Spectrum: (DMSO-d6) 2.14 (brs, 1H); 2.31 (m, 4H); 2.42 (t, 2H); 2.66 (t, 2H); 3.55 (m, 4H); 3.85 (s, 2H); 3.97 (s, 3H); 7.21 (s, 1H); 7.28 (t, 1H); 7.48 (t, 1H); 7.54 (t, 1H); 8.32 (s, 1H); 8.44 (s, 1H); 9.77 (s, 1H); Mass Spectrum: (M+H)+ 446.

Provenance & Evidence