Ethylamine → N-(3-chloro-2-fluorophenyl)-6-[(ethylamino)methyl]-7-methoxyquinazolin-4-amine

Participants

Reaction Steps

4-(3-Chloro-2-fluoroanilino)-7-methoxyquinazoline-6-carbaldehyde was coupled with ethylamine using an analogous method to that described for the equivalent step in Example 1 to give N-(3-chloro-2-fluorophenyl)-6-[(ethylamino)methyl]-7-methoxyquinazolin-4-amine; 1H NMR Spectrum: (DMSO-d6) 1.09 (t, 3H); 2.63 (q, 2H); 3.83 (s, 2H); 3.97 (s, 3H); 7.20 (s, 1H); 7.27 (t, 1H); 7.50 (m, 2H); 8.33 (s, 1H); 8.43 (s, 1H); 9.77 (s, 1H); Mass Spectrum: (M+H)+ 361.

Provenance & Evidence