HuagongsheHuagongshe Chemistry Print Report · For research reference only
Formaldehyde → HCID 57979801, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Formaldehyde | HCID 712 | — |
| Reactant | 4-[(3-Chloro-2-fluorophenyl)amino]-7-methoxyquinazoline-6-carbaldehyde | HCID 11573492 | — |
| Reactant | α-Amino-1-[(1,1-dimethylethoxy)carbonyl]-3-pyrrolidineacetic acid | HCID 22309149 | — |
| Product | HCID 57979801 | HCID 57979801 | — |
Reaction Steps
4-[(3-chloro-2-fluorophenyl)amino]-7-methoxyquinazoline-6-carbaldehyde was coupled with amino[1-(tert-butoxycarbonyl)pyrrolidin-3-yl]acetic acid, deprotected and methylated by reaction with aqueous formaldehyde using analogous methods to those described for the equivalent steps in Example 68 to give [({4-[(3-chloro-2-fluorophenyl)amino]-7-methoxyquinazolin-6-yl}methyl)(methyl)amino](1-methylpyrrolidin-3-yl)acetic acid as a pale yellow foam; Mass Spectrum: (M+H)+ 488.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07632840B2 |
| Source dataset | uspto-grants-2009_12 |
| ORD ID | ord-263fa2ca6d7c40769dcdf73ae582e758 |
| Source note | uspto-grants-2009_12 |